Szentmiklósi A J, Németh M, Cseppentö A, Szegi J, Papp J G, Szekeres L
Arch Int Pharmacodyn Ther. 1984 Jun;269(2):287-94.
The effect of moderate and severe hypoxia on the electrical and mechanical activity of isolated left atria of guinea-pigs was compared in the presence and absence of coformycin, a highly specific and tight-binding inhibitor of adenosine deaminase. The myocardial actions of hypoxia (reduction in the duration of intracellularly recorded action potentials and decrease in isometric tension, maximum velocity of contraction and relaxation as well as in time to peak tension) were significantly enhanced by coformycin, when applied in a concentration of 7 mumol/l producing nearly complete inhibition of adenosine deaminase in atrial muscle. These effects of coformycin were moderate during early hypoxia (0-5 min) and became pronounced during the late phase of oxygen deprivation (5-16 min). The results are in favour of the previous assumption that under hypoxic conditions the increased tissue level of adenosine might contribute to the functional impairment of the guinea-pig myocardium.
在存在和不存在共霉素（一种腺苷脱氨酶的高度特异性和紧密结合抑制剂）的情况下，比较了中度和重度缺氧对豚鼠离体左心房电活动和机械活动的影响。当以7μmol/L的浓度应用共霉素时，缺氧对心肌的作用（细胞内记录的动作电位持续时间缩短，等长张力、收缩和舒张的最大速度以及达到峰值张力的时间降低）显著增强，该浓度几乎完全抑制心房肌中的腺苷脱氨酶。共霉素的这些作用在早期缺氧（0-5分钟）时适中，而在缺氧后期（5-16分钟）变得明显。这些结果支持了先前的假设，即在缺氧条件下，组织中腺苷水平的升高可能导致豚鼠心肌的功能损害。
