Szentmiklósi A J, Németh M, Szegi J, Papp J G, Szekeres L
Arch Int Pharmacodyn Ther. 1979 Apr;238(2):283-95.
The effects of adenosine on transmembrane potential and myocardial contractility were compared with those of hypoxia in electrically driven left atrial preparations of guinea-pigs. The amplitude and duration of action potential, contractile force and maximum rate of rise of tension development were decreased by both adenosine and hypoxia. Both the adenosine- and hypoxia-induced changes could readily be prevented by aminophylline, a competitive antagonist of adenosine. Serious changes of transmembrane atrial potential due to long-lasting hypoxia could also be reversed by aminophylline. On the basis of the present results it is assumed that in acute myocardial hypoxia the increased tissue level of adenosine might contribute to the functional impairment of the atrial myocardium.
在豚鼠的电驱动左心房制备物中，将腺苷对跨膜电位和心肌收缩力的影响与缺氧的影响进行了比较。腺苷和缺氧均使动作电位的幅度和持续时间、收缩力以及张力发展的最大上升速率降低。腺苷和缺氧引起的变化均可被腺苷的竞争性拮抗剂氨茶碱轻易阻止。氨茶碱也可逆转由于长期缺氧导致的跨膜心房电位的严重变化。根据目前的结果推测，在急性心肌缺氧时，组织中腺苷水平的升高可能导致心房心肌的功能损害。
