中空纤维透析器提取物的免疫学研究。
Immunologic studies of hollow-fiber dialyzer extracts.
作者信息
Butcher B T, Reed M A, O'Neil C E, Leech S, Pearson F C
出版信息
Artif Organs. 1984 Aug;8(3):318-28. doi: 10.1111/j.1525-1594.1984.tb04298.x.
Testing failed to detect free isocyanates in dialyzer rinses or significant levels of immunoglobulin E antibodies to isocyanate-protein conjugates in the serum of individuals reacting during hemodialysis with dialyzers containing Cuprophan membranes. Extended immunization of rabbits with Limulus lysate-reactive material from dialyzer rinses demonstrated antigenic activity of the rinse that appears to originate from cotton linters used in hollow-fiber membranes. The possibility that an immunologic response to these antigens may be a mechanism in adverse reactions to hemodialysis is discussed.
检测未能在透析器冲洗液中检测到游离异氰酸酯，也未能在使用铜仿膜透析器进行血液透析期间出现反应的个体血清中检测到针对异氰酸酯-蛋白质缀合物的显著水平的免疫球蛋白E抗体。用透析器冲洗液中的鲎试剂反应性物质对兔子进行长期免疫，结果表明冲洗液具有抗原活性，这种活性似乎源自中空纤维膜中使用的棉绒。本文讨论了对这些抗原的免疫反应可能是血液透析不良反应机制的可能性。
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