Gotoh F, Komatsumoto S, Araki N, Gomi S
Arch Neurol. 1984 Sep;41(9):951-5. doi: 10.1001/archneur.1984.04050200057018.
The autonomic nervous function in patients with migraine was studied during headache-free intervals. The following observations were made: (1) a decrease in overshoot in Valsalva's maneuver; (2) orthostatic hypotension; (3) low levels of plasma norepinephrine in the steady state; (4) failure in elevation of the plasma norepinephrine level after head-up tilting; (5) dilatation of the pupils after instillation in the eye of 1.25% epinephrine; and (6) a long recovery time in tests by bolus injection of 0.1 microgram of norepinephrine bitartrate per kilogram. The above findings suggest that patients with migraine show sympathetic hypofunction together with denervation hypersensitivity of the iris and the arteries, and that a defective noradrenergic nervous system may play a role in the pathogenesis of migraine.
在无头痛发作期间对偏头痛患者的自主神经功能进行了研究。观察到以下情况：（1）瓦尔萨尔瓦动作中的过冲降低；（2）体位性低血压；（3）稳态时血浆去甲肾上腺素水平低；（4）头高位倾斜后血浆去甲肾上腺素水平未能升高；（5）在眼内滴入1.25%肾上腺素后瞳孔散大；以及（6）每公斤体重静脉推注0.1微克重酒石酸去甲肾上腺素的试验中恢复时间延长。上述发现表明，偏头痛患者存在交感神经功能减退以及虹膜和动脉的去神经超敏反应，并且去甲肾上腺素能神经系统缺陷可能在偏头痛的发病机制中起作用。
