• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

六个盲人摸大象：心肌中燃料代谢的各个方面以及三羧酸循环活性的调控

Six blind men explore an elephant: aspects of fuel metabolism and the control of tricarboxylic acid cycle activity in heart muscle.

作者信息

Taegtmeyer H

出版信息

Basic Res Cardiol. 1984 May-Jun;79(3):322-36. doi: 10.1007/BF01908033.

DOI:10.1007/BF01908033
PMID:6477383
Abstract

Many aspects of the interactions of energy providing substrates and the operational control of the tricarboxylic acid cycle are still unclear. This statement is well supported by the sometimes conflicting observations in heart muscle. The paper discusses some of the knowns and unknowns of tricarboxylic acid cycle regulation and discusses mechanisms of metabolite accumulation in this tissue. It is concluded that the data available at this time are insufficient to propose a unifying concept.

摘要

能量供应底物的相互作用以及三羧酸循环的运行控制的许多方面仍不清楚。心肌中有时相互矛盾的观察结果有力地支持了这一说法。本文讨论了三羧酸循环调节的一些已知和未知之处，并探讨了该组织中代谢物积累的机制。得出的结论是，目前可用的数据不足以提出一个统一的概念。

相似文献

1
Six blind men explore an elephant: aspects of fuel metabolism and the control of tricarboxylic acid cycle activity in heart muscle.六个盲人摸大象：心肌中燃料代谢的各个方面以及三羧酸循环活性的调控
Basic Res Cardiol. 1984 May-Jun;79(3):322-36. doi: 10.1007/BF01908033.
2
Mitochondrial function in the heart.
Annu Rev Physiol. 1979;41:485-506. doi: 10.1146/annurev.ph.41.030179.002413.
3
[Metabolism of fatty acids in the healthy myocardium and in ischemia].[健康心肌和缺血心肌中的脂肪酸代谢]
Vopr Med Khim. 1984 Sep-Oct;30(5):2-13.
4
[On metabolic regulation of initial reactions of the tricarboxylic cycle].[论三羧酸循环起始反应的代谢调节]
Ukr Biokhim Zh. 1977 Sep-Oct;49(5):115-29.
5
Use of the perfused rat heart to study cardiac metabolism: retrospective and prospective views.利用灌注大鼠心脏研究心脏代谢：回顾与展望
Basic Res Cardiol. 1984 May-Jun;79(3):283-91. doi: 10.1007/BF01908028.
6
Metabolic effects of pent-4-enoate in isolated perfused rat heart.戊-4-烯酸在离体灌注大鼠心脏中的代谢效应。
Biochem J. 1978 Feb 15;170(2):241-7. doi: 10.1042/bj1700241.
7
Fatty acid, tricarboxylic acid cycle metabolites, and energy metabolism in vascular smooth muscle.
Am J Physiol. 1994 Aug;267(2 Pt 2):H764-9. doi: 10.1152/ajpheart.1994.267.2.H764.
8
Tricarboxylic acid cycle flux and enzyme activities in the isolated working rat heart.离体工作大鼠心脏中的三羧酸循环通量及酶活性
Biochem J. 1981 Dec 15;200(3):701-3. doi: 10.1042/bj2000701.
9
[Mechanisms of the regulation of muscle energy metabolism on oxidation of glucose and fatty acids. A mathematical model].[葡萄糖和脂肪酸氧化时肌肉能量代谢的调节机制。一个数学模型]
Biokhimiia. 1982 Aug;47(8):1278-88.
10
The control of tricarboxylate-cycle of oxidations in blowfly flight muscle. The steady-state concentrations of coenzyme A, acetyl-coenzyme A and succinyl-coenzyme A in flight muscle and isolated mitochondria.丽蝇飞行肌中氧化三羧酸循环的调控。飞行肌和分离线粒体中辅酶A、乙酰辅酶A和琥珀酰辅酶A的稳态浓度。
Biochem J. 1974 Sep;142(3):509-19. doi: 10.1042/bj1420509.

引用本文的文献

1
Hyperpolarized [1-C]Acetyl-l-Carnitine Probes Tricarboxylic Acid Cycle Activity .高极化 [1-C]乙酰左旋肉碱探针三羧酸循环活性。
ACS Sens. 2023 Aug 25;8(8):2927-2932. doi: 10.1021/acssensors.3c01046. Epub 2023 Aug 14.
2
Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate.使用超极化的[1-(13)C]丁酸盐和[1-(13)C]丙酮酸盐测量心肌中底物利用情况对禁食的反应变化。
Sci Rep. 2016 May 6;6:25573. doi: 10.1038/srep25573.
3
Oxygen demand of perfused heart preparations: how electromechanical function and inadequate oxygenation affect physiology and optical measurements.

本文引用的文献

1
Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle.碳水化合物与脂质代谢及心肌能量平衡之间的关系。
Annu Rev Physiol. 1974;36:413-59. doi: 10.1146/annurev.ph.36.030174.002213.
2
The effect of glucose on the gaseous metabolism of the isolated mammalian heart.葡萄糖对离体哺乳动物心脏气体代谢的影响。
J Physiol. 1914 Feb 27;47(6):407-18. doi: 10.1113/jphysiol.1914.sp001633.
3
An Attempt to estimate the Gaseous Interchange of the Frog's Heart by Means of the Spectroscope.用分光镜估算青蛙心脏气体交换的尝试。
灌注心脏制剂的氧需求：机电功能和氧合不足如何影响生理学和光学测量。
Exp Physiol. 2015 Jun;100(6):603-16. doi: 10.1113/EP085042.
4
Evidence for transaldolase activity in the isolated heart supplied with [U-13C3]glycerol.用 [U-13C3]甘油供给分离心脏时的醛缩酶活性证据。
J Biol Chem. 2013 Feb 1;288(5):2914-22. doi: 10.1074/jbc.M112.409441. Epub 2012 Dec 12.
5
Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate.丙酮酸与生理底物竞争心脏氧化：对用 1-13C 标记的[1-13C]丙酮酸进行研究的影响。
Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1556-64. doi: 10.1152/ajpheart.00656.2009. Epub 2010 Mar 5.
6
Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-.短暂缺血后再灌注第一分钟内碳水化合物氧化的抑制：超极化13CO2和H13CO3-的核磁共振检测
Magn Reson Med. 2008 Nov;60(5):1029-36. doi: 10.1002/mrm.21760.
7
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.超极化13C能够通过核磁共振直接测量单个酶催化步骤的通量。
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19773-7. doi: 10.1073/pnas.0706235104. Epub 2007 Dec 3.
8
Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation.高心脏能量产生过程中丙酮酸脱氢酶活性和柠檬酸循环中间体的调节
J Physiol. 2005 Jan 15;562(Pt 2):593-603. doi: 10.1113/jphysiol.2004.075713. Epub 2004 Nov 18.
9
A comparison between NMR and GCMS 13C-isotopomer analysis in cardiac metabolism.核磁共振（NMR）与气相色谱-质谱联用（GCMS）13C-同位素异构体分析在心脏代谢中的比较。
Mol Cell Biochem. 2003 Jul;249(1-2):105-12.
10
Myocardial H2O2 production in the unanaesthetized rat. Influence of fasting, myocardial load and inhibition of superoxide dismutase and monoamine oxidase.未麻醉大鼠心肌过氧化氢的产生。禁食、心肌负荷以及超氧化物歧化酶和单胺氧化酶抑制的影响。
Basic Res Cardiol. 1986 Jan-Feb;81(1):83-91. doi: 10.1007/BF01907430.
J Physiol. 1885 May;6(3):93-121. doi: 10.1113/jphysiol.1885.sp000186.
4
Steady-state concentrations of coenzyme A, acetyl-coenzyme A and long-chain fatty acyl-coenzyme A in rat-liver mitochondria oxidizing palmitate.在氧化棕榈酸酯的大鼠肝脏线粒体中辅酶A、乙酰辅酶A和长链脂肪酰辅酶A的稳态浓度。
Biochem J. 1965 Nov;97(2):587-94. doi: 10.1042/bj0970587.
5
The interconversion of glutamic acid and aspartic acid in respiring tissues.呼吸组织中谷氨酸和天冬氨酸的相互转化。
Biochem J. 1960 Jun;75(3):523-9. doi: 10.1042/bj0750523.
6
[ON THE SIGNIFICANCE OF ACETOACETATE AND BETA-HYDROXYBUTYRATE IN HUMAN MYOCARDIAL METABOLISM].[关于乙酰乙酸和β-羟基丁酸在人体心肌代谢中的意义]
Klin Wochenschr. 1965 Apr 15;43:445-51. doi: 10.1007/BF01483852.
7
GLYCOLYTIC CONTROL MECHANISMS. I. INHIBITION OF GLYCOLYSIS BY ACETATE AND PYRUVATE IN THE ISOLATED, PERFUSED RAT HEART.糖酵解控制机制。一、乙酸盐和丙酮酸盐对离体灌注大鼠心脏糖酵解的抑制作用
J Biol Chem. 1965 Jun;240:2308-21.
8
EFFECT OF CARNITINE ON THE OXIDATION OF ALPHA-OXOGLUTARATE TO SUCCINATE IN THE PRESENCE OF ACETOACETATE OR PYRUVATE.肉碱在存在乙酰乙酸或丙酮酸的情况下对α-酮戊二酸氧化为琥珀酸的影响。
Biochim Biophys Acta. 1964 Oct 9;93:166-8. doi: 10.1016/0304-4165(64)90271-5.
9
INHIBITION OF GLYCOLYSIS BY PYRUVATE IN RELATION TO THE ACCUMULATION OF CITRIC ACID CYCLE INTERMEDIATES IN THE PERFUSED RAT HEART.丙酮酸对糖酵解的抑制作用与灌注大鼠心脏中柠檬酸循环中间产物的积累的关系
Nature. 1964 Sep 12;203:1171-3. doi: 10.1038/2031171a0.
10
OXIDATION OF CARBON-14-LABELED ENDOGENOUS LIPIDS BY ISOLATED PERFUSED RAT HEART.离体灌注大鼠心脏对碳-14标记的内源性脂质的氧化作用
Science. 1964 Jan 24;143(3604):371-3. doi: 10.1126/science.143.3604.371.