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高铁细胞色素b5将氧合血红蛋白转化为高铁血红蛋白。

Conversion of oxyhaemoglobin into methaemoglobin by ferricytochrome b5.

作者信息

Mauk M R, Reid L S, Mauk A G

出版信息

Biochem J. 1984 Jul 15;221(2):297-302. doi: 10.1042/bj2210297.

DOI:10.1042/bj2210297
PMID:6477474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144039/
Abstract

Ferricytochrome b5 was found to convert oxyhaemoglobin into methaemoglobin under conditions previously found to be optimal for complex-formation between ferricytochrome b5 and methaemoglobin [Mauk & Mauk (1982) Biochemistry 21, 4730-4734]. As this reaction is completely inhibited by CO, it is proposed that oxyhaemoglobin is oxidized after O2 dissociation, as has been suggested for the oxidation of oxyhaemoglobin by inorganic complexes. From the present analysis, ferricytochrome b5 seems unlikely to contribute significantly to methaemoglobin formation in vivo. Nevertheless, this observation provides a relatively convenient means of investigating the mechanism by which these two proteins interact.

摘要

已发现高铁细胞色素b5在先前发现的有利于高铁细胞色素b5与高铁血红蛋白形成复合物的最佳条件下，可将氧合血红蛋白转化为高铁血红蛋白[莫克和莫克（1982年）《生物化学》21卷，4730 - 4734页]。由于该反应完全被一氧化碳抑制，因此有人提出，氧合血红蛋白在氧气解离后被氧化，这与无机复合物对氧合血红蛋白的氧化情况一致。从目前的分析来看，高铁细胞色素b5似乎不太可能在体内显著促进高铁血红蛋白的形成。然而，这一观察结果为研究这两种蛋白质相互作用的机制提供了一种相对便捷的方法。

相似文献

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Conversion of oxyhaemoglobin into methaemoglobin by ferricytochrome b5.高铁细胞色素b5将氧合血红蛋白转化为高铁血红蛋白。
Biochem J. 1984 Jul 15;221(2):297-302. doi: 10.1042/bj2210297.
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STUDIES ON THE OXIDATION-REDUCTION POTENTIALS OF HEME PROTEINS. IV. THE KINETICS OF OXIDATION OF HEMOGLOBIN AND MYOGLOBIN BY FERRICYANIDE.血红素蛋白氧化还原电位的研究。IV. 铁氰化物氧化血红蛋白和肌红蛋白的动力学
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THE INTERACTION OF PORPHYRINS AND METALLOPORHYRINS WITH APOCYTOCHROME BETA-5.卟啉和金属卟啉与脱辅基细胞色素β-5的相互作用
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STUDIES ON THE OXIDATION-REDUCTION POTENTIALS OF HEME PROTEINS. I. HUMAN HEMOGLOBIN.血红素蛋白氧化还原电位的研究。I. 人血红蛋白
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Stopped-flow, rapid mixing measurements of ligand binding to hemoglobin and red cells.用于测量配体与血红蛋白及红细胞结合的停流快速混合测量法。
Methods Enzymol. 1981;76:631-51. doi: 10.1016/0076-6879(81)76148-2.
5
Properties of methemoglobin reductase and kinetic study of methemoglobin reduction.高铁血红蛋白还原酶的性质及高铁血红蛋白还原的动力学研究
J Biol Chem. 1981 Jun 10;256(11):5518-23.
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Interaction between cytochrome b5 and human methemoglobin.细胞色素b5与人类高铁血红蛋白之间的相互作用。
Biochemistry. 1982 Sep 14;21(19):4730-4. doi: 10.1021/bi00262a032.
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Demonstration that bovine erythrocyte cytochrome b5 is the hydrophilic segment of liver microsomal cytochrome b5.证明牛红细胞细胞色素b5是肝微粒体细胞色素b5的亲水性片段。
Biochim Biophys Acta. 1982 Jul 26;705(2):228-37. doi: 10.1016/0167-4838(82)90182-0.
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Initial rates. A new plot.初始速率。一种新的图表。
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Oxidation of carbonyl hemoglobins by ferricyanide. Hemoglobins A, Osler (beta 145 Tyr replaced by Asp) and Zurich (beta 63 His replaced by Arg).高铁氰化物对羰基血红蛋白的氧化作用。血红蛋白A、奥斯勒血红蛋白（β145位酪氨酸被天冬氨酸取代）和苏黎世血红蛋白（β63位组氨酸被精氨酸取代）。
Eur J Biochem. 1982 Nov 15;128(2-3):521-5.
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Models for the complexes formed between cytochrome b5 and the subunits of methemoglobin.细胞色素b5与高铁血红蛋白亚基之间形成的复合物模型。
J Biol Chem. 1983 Jun 25;258(12):7369-73.

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