受刺激的人中性粒细胞中磷脂酰肌醇、磷脂酸和1,2 - 二酰基甘油的脂肪酸组成
The fatty acid composition of phosphatidylinositol, phosphatidate and 1,2-diacylglycerol in stimulated human neutrophils.
作者信息
Cockcroft S, Allan D
出版信息
Biochem J. 1984 Sep 1;222(2):557-9. doi: 10.1042/bj2220557.
Abstract
The fatty acid composition of phosphatidylinositol (PtdIns), phosphatidate (PtdOH) and 1,2-diacylglycerol (DG) was determined in cytochalasin B-treated human neutrophils in the presence and in the absence of formylmethionyl-leucyl-phenylalanine. The compositions of PtdOH and DG in stimulated cells resemble closely that of PtdOH in control cells and are quite different from the composition of PtdIns. DG appears to be produced as a subsequent metabolite of PtdOH and not as an intermediate in the conversion of PtdIns into PtdOH. We conclude that PtdOH is produced directly from a small pool of newly synthesized PtdIns in stimulated neutrophils.
摘要
在存在和不存在甲酰甲硫氨酰-亮氨酰-苯丙氨酸的情况下，测定了细胞松弛素B处理的人中性粒细胞中磷脂酰肌醇（PtdIns）、磷脂酸（PtdOH）和1,2-二酰基甘油（DG）的脂肪酸组成。刺激细胞中PtdOH和DG的组成与对照细胞中PtdOH的组成非常相似，与PtdIns的组成有很大不同。DG似乎是作为PtdOH的后续代谢产物产生的，而不是作为PtdIns转化为PtdOH的中间体。我们得出结论，PtdOH是由刺激的中性粒细胞中新合成的一小部分PtdIns直接产生的。
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