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人红细胞膜中1,2 - 二酰基甘油和多磷酸肌醇的脂肪酸组成。

The fatty acid composition of 1,2-diacylglycerol and polyphosphoinositides from human erythrocyte membranes.

作者信息

Allan D, Cockcroft S

出版信息

Biochem J. 1983 Aug 1;213(2):555-7. doi: 10.1042/bj2130555.

DOI:10.1042/bj2130555
PMID:6311167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1152163/
Abstract

The fatty acid compositions of 1,2-diacylglycerol and polyphosphoinositides have been determined in human erythrocyte membranes that have been incubated in the presence or in the absence of Ca2+. The results show that the diacylglycerol that is formed in Ca2+-treated membranes has a fatty acid composition closely similar to that of the inositides, consistent with previous indications that Ca2+ stimulates the activity of a polyphosphoinositide phosphodiesterase in the membranes. In contrast with some previous results, it appears that these plasma-membrane inositides and their derived diacylglycerols are rich in stearic acid and arachidonic acid.

摘要

已测定在有或无Ca2+存在的情况下孵育的人红细胞膜中1,2 - 二酰基甘油和多磷酸肌醇的脂肪酸组成。结果表明,在经Ca2+处理的膜中形成的二酰基甘油的脂肪酸组成与肌醇磷脂的脂肪酸组成非常相似,这与之前关于Ca2+刺激膜中多磷酸肌醇磷酸二酯酶活性的迹象一致。与之前的一些结果相反,这些质膜肌醇磷脂及其衍生的二酰基甘油似乎富含硬脂酸和花生四烯酸。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68b/1152163/4f488e44eb09/biochemj00347-0273-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68b/1152163/4f488e44eb09/biochemj00347-0273-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68b/1152163/4f488e44eb09/biochemj00347-0273-a.jpg

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本文引用的文献

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二酰基甘油的短暂增加与血管加压素对肝细胞的作用有关。
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Evidence from studies employing radioactively labelled fatty acids that the stimulation of flux through the diacylglycerol pool is an early action of vasopressin on hepatocytes.采用放射性标记脂肪酸的研究证据表明,通过二酰甘油池的通量刺激是血管加压素对肝细胞的早期作用。
Biochem J. 1987 Jul 1;245(1):211-6. doi: 10.1042/bj2450211.
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