糖异生作用和生酮作用之间可能存在相互关系的证据？
Evidence for possible interrelationship between gluconeogenesis and ketogenesis?
作者信息
Kümmel L
出版信息
Biochem Int. 1984 Mar;8(3):393-400.
Effects of ketogenic substrates on gluconeogenesis by rat hepatocytes were examined. D,L-3-Hydroxybutyrate (5 mM) stimulated gluconeogesis from lactate by 41%, the effect being the same as that of 5 mM acetate (43%). Acetoacetate up to 40 mM had no stimulating effect; conversely, it partially or completely abolished the observed stimulating effects of acetate, 3-hydroxybutyrate, or oleate. 3-Hydroxybutyrate also stimulated gluconeogenesis from serine by 70%, the effect being much higher than that of acetate (35%). No effect of 3-hydroxybutyrate or acetate on gluconeogenesis from pyruvate was seen. It is proposed that, in intact liver cells, pyruvate is transported into mitochondria in exchange for intramitochondrially generated acetoacetate, and that the mechanism proposed may be of physiological importance.
研究了生酮底物对大鼠肝细胞糖异生的影响。D，L-3-羟基丁酸（5 mM）使乳酸生成葡萄糖的糖异生作用增强了41%，其效果与5 mM乙酸盐（43%）相同。高达40 mM的乙酰乙酸没有刺激作用；相反，它部分或完全消除了观察到的乙酸盐、3-羟基丁酸或油酸的刺激作用。3-羟基丁酸还使丝氨酸生成葡萄糖的糖异生作用增强了70%，其效果远高于乙酸盐（35%）。未观察到3-羟基丁酸或乙酸盐对丙酮酸生成葡萄糖的糖异生作用有影响。有人提出，在完整的肝细胞中，丙酮酸被转运到线粒体中，以交换线粒体内产生的乙酰乙酸，并且所提出的机制可能具有生理重要性。
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