[两性霉素B对离体灌注大鼠肝脏的胆汁淤积作用。初步观察]
[Cholestatic effect of amphotericin B on the isolated perfused rat liver. Preliminary observations].
作者信息
Gaeta G B, Tripodi M F, Adinolfi L E, Utili R
出版信息
Boll Soc Ital Biol Sper. 1984 Jun 30;60(6):1177-81.
PMID:6477733
Abstract
We evaluated the effect of Amphotericin B, a polyen antimycotic agent, on the excretory functions of the isolated perfused rat liver. At 5 X 10(-6) and 10(-5) M, Amphotericin caused a rapid dose-dependent cholestasis. This effect was paralleled by an increase in canalicular permeability, as evaluated by sucrose C14 B/P ratio. The data indicate that Amphotericin B is a potent cholestatic agent in vitro and suggest that caution should be exercised in the use of this drug in hepatopatic patients.
摘要
我们评估了多烯抗真菌药两性霉素B对离体灌注大鼠肝脏排泄功能的影响。在5×10⁻⁶和10⁻⁵ M浓度下，两性霉素引起迅速的剂量依赖性胆汁淤积。通过蔗糖C¹⁴ B/P比值评估，这种效应与胆小管通透性增加平行。数据表明两性霉素B在体外是一种强效的胆汁淤积剂，并提示在肝病患者中使用该药时应谨慎。
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