Karmazsin L, Balla G, Misz M, Beck P, Nagy P, Rák K
Acta Paediatr Hung. 1984;25(1-2):119-26.
The plasma antithrombin III level was measured in term and premature newborns within the first 24 h of life; in addition to the authors', own immunological method utilizing rate nephelometry the assays of Laurell and Kabi Coatest were used. Antithrombin III concentration showed a linear correlation with the degree of maturity, in accordance with previous data. The lowest values were found in premature babies affected by idiopathic respiratory distress syndrome who later developed pulmonary haemorrhage. At all gestational ages the antithrombin III functional index was lower than 1.0, indicating antithrombin III consumption. Since both concentration and activity of antithrombin III are low in prematures, they are at an increased risk for coagulopathies, hence substitution therapy is indicated. Measurement of antithrombin III by rate nephelometry can also be used for following changes in inhibitor concentration.
在足月和早产新生儿出生后的头24小时内测定血浆抗凝血酶III水平；除了作者自己利用速率散射比浊法的免疫学方法外，还使用了劳雷尔法和卡比公司的检测方法。抗凝血酶III浓度与成熟度呈线性相关，与先前的数据一致。在患有特发性呼吸窘迫综合征且后来发生肺出血的早产儿中发现了最低值。在所有孕周，抗凝血酶III功能指数均低于1.0，表明抗凝血酶III消耗。由于早产儿的抗凝血酶III浓度和活性均较低，他们发生凝血病的风险增加，因此需要进行替代治疗。通过速率散射比浊法测定抗凝血酶III也可用于监测抑制剂浓度的变化。
