Nakamura Y, Abbott R, Hasuo Y, Takeshita T, Nishimura K, Shinagawa S
Biol Res Pregnancy Perinatol. 1984;5(3):110-2.
A study involving the determination of total fibrinogen and high molecular weight (HMW) fibrinogen was performed with the glycine precipitation method. Ninety patients in different trimesters of pregnancy and 37 non-pregnant controls participated in the study. Total fibrinogen was found to increase during pregnancy until delivery, after which it declined gradually, peaking once more on the 3rd day of puerperium. HMW fibrinogen showed a similar pattern during pregnancy and puerperium, but markedly increased at the time of delivery. These elevated values during pregnancy indicate a significant change in the fibrinolytic system, which is believed to be depressed during pregnancy, enhanced during the postpartum period, and stabilized after the 3rd day of puerperium.
采用甘氨酸沉淀法进行了一项关于总纤维蛋白原和高分子量（HMW）纤维蛋白原测定的研究。90名处于不同孕期的孕妇和37名非孕对照者参与了该研究。发现总纤维蛋白原在孕期直至分娩时升高，之后逐渐下降，在产褥期第3天再次达到峰值。HMW纤维蛋白原在孕期和产褥期呈现类似模式，但在分娩时显著升高。孕期这些升高的值表明纤维蛋白溶解系统发生了显著变化，据信该系统在孕期受到抑制，在产后时期增强，并在产褥期第3天后稳定。
