Takahashi T, Furuhashi N, Tanaka M, Takahashi T, Hiruta M, Suzuki M
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Jul;37(7):1112-6.
There have been few reports about the changes in active and inactive renin throughout pregnancy. In this study, the changes in total and active renin concentrations during pregnancy were measured and their physiological roles are discussed. The present method employed radioimmunoassay of angiotensin I generated during incubation of plasma in an excess of sheep renin substrate. For determination of total renin concentration, inactive renin was activated by exposing plasma to trypsin. Concurrent with the progress of pregnancy, active renin increased gradually and reached its maximum during the third trimester, then fell sharply to first trimester levels by the fifth day of the puerperium. Total renin levels during pregnancy were about twice as high as puerperal levels. We found no difference in total renin levels between trimesters but a marked difference in individual women was observed. In the first trimester of pregnancy, inactive renin in plasma rapidly increased (to 4 times the average concentration in plasma of puerperal women), then declined slowly throughout pregnancy, and fell quickly after delivery. These results suggest that in pregnancy total renin levels are consistently elevated, 67% of which is inactive renin in the first trimester and active renin increases gradually with advancing gestation. After delivery, both active and inactive renin fall to normal levels within a few days.
关于整个孕期活性肾素和非活性肾素的变化，相关报道较少。在本研究中，对孕期总肾素和活性肾素浓度的变化进行了测定，并对其生理作用进行了讨论。本方法采用放射免疫分析法检测在过量羊肾素底物中孵育血浆时生成的血管紧张素I。为了测定总肾素浓度，通过将血浆暴露于胰蛋白酶来激活非活性肾素。随着孕期进展，活性肾素逐渐增加，在孕晚期达到最大值，然后在产后第5天急剧降至孕早期水平。孕期总肾素水平约为产后水平的两倍。我们发现各孕期之间总肾素水平没有差异，但在个体女性中观察到明显差异。在妊娠早期，血浆中的非活性肾素迅速增加（达到产后女性血浆平均浓度的4倍），然后在整个孕期缓慢下降，并在分娩后迅速下降。这些结果表明，孕期总肾素水平持续升高，其中67%在孕早期为非活性肾素，活性肾素随着孕周增加而逐渐增加。分娩后，活性和非活性肾素在几天内均降至正常水平。
