血管紧张素II并不抑制麻醉雪貂的迷走神经诱导的心动过缓或胃收缩。
Angiotensin II does not inhibit vagally-induced bradycardia or gastric contractions in the anaesthetized ferret.
作者信息
Andrews P L, Dutia M B, Harris P J
出版信息
Br J Pharmacol. 1984 Aug;82(4):833-7. doi: 10.1111/j.1476-5381.1984.tb16480.x.
The effects of angiotensin II (AII) and the analogue Sar1-Leu8-angiotensin II on the changes in heart rate and gastric pressure induced by vagal stimulation were investigated in the urethane-anaesthetized ferret. AII at high doses (500 ng kg-1 i.v.) increased blood pressure and decreased gastric pressure whereas Sar1-Leu8-AII at the same dose had a much smaller effect on blood pressure and no effect on gastric pressure. Intravenous injections or infusions of AII or its analogue did not alter the effect of vagal stimulation on heart rate or gastric motility. Our results do not provide support for the proposal that AII modulates parasympathetic activity at peripheral sites (Potter, 1982a, b).
在氨基甲酸乙酯麻醉的雪貂中，研究了血管紧张素II（AII）及其类似物Sar1-Leu8-血管紧张素II对迷走神经刺激引起的心率和胃内压变化的影响。高剂量（500 ng kg-1静脉注射）的AII可升高血压并降低胃内压，而相同剂量的Sar1-Leu8-AII对血压的影响小得多，对胃内压无影响。静脉注射或输注AII或其类似物不会改变迷走神经刺激对心率或胃动力的作用。我们的结果不支持AII在外周部位调节副交感神经活动的提议（Potter，1982a，b）。
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