Propafenone for the treatment of severe ventricular arrhythmias.
作者信息
Rabkin S W, Rotem C E, Boroomand-Rashti K, Bar-Shlomo B
出版信息
Can Med Assoc J. 1984 Sep 15;131(6):601-3.
Abstract
Twenty-one patients whose severe ventricular arrhythmias were not controlled by other currently used antiarrhythmic agents or who were intolerant of those drugs were treated with a new antiarrhythmic agent, propafenone. This therapy was associated with complete or nearly complete suppression of premature ventricular beats in 15 (71%) of the patients, satisfactory control in 4 (19%) and no control in 2 (10%). The majority reported no adverse effects. The most frequent complaints were nausea or epigastric discomfort (in five patients) and lightheadedness or dizziness (in three patients). Thus, propafenone appeared to be an effective antiarrhythmic agent with an acceptable frequency of side effects when administered to patients whose ventricular arrhythmias were difficult to treat.
摘要
相似文献
1
Propafenone for the treatment of severe ventricular arrhythmias.
Can Med Assoc J. 1984 Sep 15;131(6):601-3.
2
[Anti-arrhythmic effect of oral propafenone. Apropos of 70 cases].口服普罗帕酮的抗心律失常作用。附70例报告
Arch Mal Coeur Vaiss. 1984 Nov;77(12):1370-82.
3
[The treatment of arrhythmias in infants and children using propafenone].[普罗帕酮治疗婴幼儿心律失常]
Monatsschr Kinderheilkd. 1985 Mar;133(3):154-7.
4
Clinical evaluation of new antiarrhythmic agents: experiences with propafenone.
Int J Clin Pharmacol Res. 1983;3(2):101-5.
5
[Propafenone in ventricular hyperkinetic arrhythmias. Dynamic ECG evaluation of the acute oral test and short-term treatment].
G Ital Cardiol. 1986 Apr;16(4):328-32.
6
Holter monitoring comparative assessment of propafenone and dihydroquinidine efficacy in the treatment of premature ventricular beats.
Cardiologia. 1983 Sep;28(9):791-801.
7
Comparison of the efficacy of propafenone versus disopyramide for complex premature ventricular contractions. Evaluation with long-term monitoring.
Arzneimittelforschung. 1982;32(5):547-50.
8
[Propafenone: a new anti-arrhythmic agent for the treatment of ventricular ectopic beats].
Cardiologia. 1982;27(2):211-7.
9
[Diprafenone--comparative study of anti-arrhythmia therapy with propafenone].
Z Kardiol. 1988 Jul;77(7):464-9.
10
Worsening of arrhythmias during pharmacological treatment.
G Ital Cardiol. 1984 Oct;14(10):798-803.
引用本文的文献
1
Propafenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias.普罗帕酮。对其药效学和药代动力学特性以及在心律失常治疗中的治疗用途的综述。
Drugs. 1987 Dec;34(6):617-47. doi: 10.2165/00003495-198734060-00001.
本文引用的文献
1
Relationship of ventricular ectopy in men without apparent heart disease to occurrence of ischemic heart disease and sudden death.
Am Heart J. 1981 Feb;101(2):135-142. doi: 10.1016/0002-8703(81)90655-4.
2
Electrophysiological effects of propafenone studied with programmed electrical stimulation of the heart in patients with recurrent paroxysmal supraventricular tachycardia.采用程控心脏电刺激法研究普罗帕酮对反复发作阵发性室上性心动过速患者的电生理效应。
Eur Heart J. 1981 Aug;2(4):345-52. doi: 10.1093/oxfordjournals.eurheartj.a061215.
3
Suppression of ventricular arrhythmias by propafenone, a new antiarrhythmic agent, during acute myocardial infarction in the conscious dog. A comparative study with lidocaine.新型抗心律失常药物普罗帕酮对清醒犬急性心肌梗死期间室性心律失常的抑制作用。与利多卡因的比较研究。
Circulation. 1982 Dec;66(6):1190-8. doi: 10.1161/01.cir.66.6.1190.
4
Clinical pharmacology of propafenone.普罗帕酮的临床药理学。
Circulation. 1983 Sep;68(3):589-96. doi: 10.1161/01.cir.68.3.589.
5
Electrophysiological and antiarrhythmic properties of propafenon in isolated cardiac preparations.普罗帕酮在离体心脏标本中的电生理及抗心律失常特性。
J Cardiovasc Pharmacol. 1981 Nov-Dec;3(6):1162-73. doi: 10.1097/00005344-198111000-00002.
6
Inhibition of Vmax of the action potential by propafenone and its voltage-, time- and pH-dependence in mammalian ventricular myocardium.普罗帕酮对哺乳动物心室肌动作电位Vmax的抑制作用及其电压、时间和pH依赖性
Naunyn Schmiedebergs Arch Pharmacol. 1980;315(1):55-62. doi: 10.1007/BF00504230.
7
The posthospital phase of myocardial infarction: identification of patients with increased mortality risk.
Circulation. 1974 Mar;49(3):460-6. doi: 10.1161/01.cir.49.3.460.
8
Prognostic significance of ventricular ectopic beats with respect to sudden death in the late postinfarction period.
Circulation. 1973 May;47(5):959-66. doi: 10.1161/01.cir.47.5.959.
9
The effect of X-irradiation on the alanine--and aspartate aminotransferase activity in the liver, kidney and spleen of mouse.X射线照射对小鼠肝脏、肾脏和脾脏中丙氨酸和天冬氨酸转氨酶活性的影响。
Acta Physiol Pol. 1975 Jan-Feb;26(1):95-101.
10
Correlation between serum concentration and pharmacological effect on atrioventricular conduction time of the antiarrhythmic drug propafenone.
Eur J Clin Pharmacol. 1978 Mar 17;13(1):17-20. doi: 10.1007/BF00606676.
Zotero 插件