Schachner M, Huang S K, Ziegelmüller P, Bizzini B, Taugner R
Cell Tissue Res. 1984;237(2):245-52. doi: 10.1007/BF00217142.
Antigenic markers characteristic of astrocytes and their differentiative states (i.e., glial fibrillary acidic protein (GFAP), vimentin, and M1 and C1 antigens) were investigated in the pineal gland of mouse and rat using double immunolabeling techniques. In both species the so-called interstitial cells as characterized by TEM were shown to be astrocytes, since they expressed vimentin, but neither fibronectin (a marker for fibroblasts and endothelial cells) nor the neuron-specific L1 antigen or tetanus toxin receptors. Subpopulations of vimentin-positive pineal astrocytes were also GFAP- and C1- antigen-positive. M1- antigen-positive cells were not detected. It is concluded that a considerable proportion of interstitial cells in the pineal gland of rat and mouse are immature astrocytes which, in contrast to other parts of the central nervous system, persist into adulthood.
使用双重免疫标记技术，在小鼠和大鼠的松果体中研究了星形胶质细胞及其分化状态的抗原标志物（即胶质纤维酸性蛋白（GFAP）、波形蛋白以及M1和C1抗原）。在这两个物种中，经透射电子显微镜（TEM）鉴定的所谓间质细胞被证明是星形胶质细胞，因为它们表达波形蛋白，但不表达纤连蛋白（成纤维细胞和内皮细胞的标志物）、神经元特异性L1抗原或破伤风毒素受体。波形蛋白阳性的松果体星形胶质细胞亚群也呈GFAP和C1抗原阳性。未检测到M1抗原阳性细胞。得出的结论是，大鼠和小鼠松果体中的相当一部分间质细胞是未成熟的星形胶质细胞，与中枢神经系统的其他部分不同，它们会持续到成年期。
