Allgrove J, Sangal A K, Low D C, Weller P H, Loveridge N
Clin Endocrinol (Oxf). 1984 Sep;21(3):293-8. doi: 10.1111/j.1365-2265.1984.tb03472.x.
Biologically active PTH (bio-PTH) has been assayed by the cytochemical bioassay in five members (three affected) of a family with typical features of familial hypocalciuric hypercalcaemia (FHH). Carboxy-terminal immunoreactive PTH was undetectable and bio-PTH was within the normal range in all the subjects regardless of whether or not they were hypercalcaemic. These results suggest that increased biological activity of circulating PTH cannot account for the hypercalcaemia of FHH.
采用细胞化学生物测定法对一个具有家族性低钙血症性高钙血症（FHH）典型特征的家族中的五名成员（三名患者）进行了生物活性甲状旁腺激素（bio-PTH）检测。无论受试者是否存在高钙血症，所有受试者的羧基末端免疫反应性甲状旁腺激素均无法检测到，且bio-PTH均在正常范围内。这些结果表明，循环中甲状旁腺激素生物活性的增加不能解释FHH的高钙血症。
