Goldberg S J, Areias J C, Spitaels S E, de Villeneuve V H
Circulation. 1978 Jul;58(1):147-52. doi: 10.1161/01.cir.58.1.147.
The primary purpose of this study was to attempt to select, by examination of the time interval histogram (TIH) output of a range gated pulsed Doppler (RGPD), all children with left-to-right shunt at the atrial level from a pool of 57 children. Fifty-four of the children had various forms of acyanostic cardiac disease. A secondary purpose was to identify any associated lesions in those children with atrial defects. Examiners were unfamiliar with the children and their diagnoses. Results were interpreted independently by two examiners. Detection of diastolic TIH dispersion was used when studying the right atrial outflow tract to separate children with atrial left-to-right shunts from control children. All controls were judged negative by this technique, and 13 of 14 children with atrial shunts were detected by both examiners; the 14th was detected by one examiner. Of a total of 308 TIH decisions on the atrial shunt group, 298 were made identically by both examiners for a 97.7% agreement, demonstrating the objectivity of the method. This study demonstrated the usefulness of the TIH evaluation, indicating that continued investigation and equipment improvements are warranted.
本研究的主要目的是通过检查距离选通脉冲多普勒（RGPD）的时间间隔直方图（TIH）输出，从57名儿童中筛选出所有心房水平存在左向右分流的儿童。其中54名儿童患有各种形式的无青紫型心脏病。次要目的是确定那些患有房缺的儿童是否存在任何相关病变。检查人员不了解这些儿童及其诊断情况。结果由两名检查人员独立解读。在研究右心房流出道时，使用舒张期TIH离散度来区分有心房左向右分流的儿童和对照儿童。所有对照儿童经该技术判断均为阴性，14名有心房分流的儿童中有13名被两名检查人员均检测到；第14名仅被一名检查人员检测到。在对心房分流组总共308次TIH判断中，两名检查人员的判断完全一致的有298次，一致性为97.7%，证明了该方法的客观性。本研究证明了TIH评估的有用性，表明有必要继续进行研究并改进设备。
