Mirowski M, Mower M M, Langer A, Heilman M S, Schreibman J
Circulation. 1978 Jul;58(1):90-4. doi: 10.1161/01.cir.58.1.90.
Ventricular defibrillation was acheived in active conscious dogs with a chronically implanted automatic system composed of a defibrillator and an alternating current fibrillator. The hermetically sealed defibrillator is encased in titanium, weighs 250 g and has a volume of 145 ml. The sensor continuously monitors ventricular electircal activity and recognizes fibrillation by the absence of isoelectric potential segments. Fibrillation is induced by placing a magnet over the implanted fibrillator. The resulting syncope closely resembles the clinical entity of sudden death, while the defibrillator automatically restores normal rhythm with a truncated exponential pulse of 30 J, 15 seconds after the onset of the arrhythmia. The operational status of the defibrillator can be tested in vitro and noninvasively in vivo with an external analyzer. This experimental model allows for the first time a long-term study of the automatic implantable defibrillator approach to prevent sudden death from ventricular fibrillation under a variety of physiopathologic conditions.
使用一个由除颤器和交流心脏纤维颤动器组成的长期植入式自动系统，在清醒的活动犬身上实现了心室除颤。这个密封的除颤器由钛制成外壳，重250克，体积为145毫升。传感器持续监测心室电活动，并通过等电位段的缺失来识别纤维颤动。通过将一块磁铁放在植入的心脏纤维颤动器上诱发纤维颤动。由此产生的晕厥与猝死的临床症状极为相似，而除颤器会在心律失常发作15秒后，自动用一个30焦耳的截断指数脉冲恢复正常节律。除颤器的运行状态可以在体外进行测试，也可以通过外部分析仪在体内进行非侵入性测试。这个实验模型首次使得在各种生理病理条件下，能够对自动植入式除颤器预防心室纤维颤动导致的猝死方法进行长期研究。
