Young R S, Yagel S K, Gonya-Magee T
Epilepsia. 1984 Oct;25(5):569-73. doi: 10.1111/j.1528-1157.1984.tb03463.x.
The effect of asphyxia on seizures was determined in neonatal dogs. In normoxic (paralyzed and ventilated) neonatal dogs, bicuculline-induced seizures produced significant elevations of arterial blood pressure, PO2, glucose, lactate, and epinephrine. Cerebral blood flow increased severalfold; brain glucose, adenosine triphosphate (ATP), and phosphocreatine (PCr) did not decrease significantly. In contrast, seizures during asphyxia were associated with hypoxia, hypotension, hypercarbia, and acidosis. Significant cerebral ischemia developed. Brain glucose, ATP, and PCr were significantly depleted. Complete oxygen deprivation during neonatal seizures exhausts brain energy stores, which leads to cessation of seizure activity.
在新生犬中测定了窒息对癫痫发作的影响。在常氧（麻痹并通气）的新生犬中，荷包牡丹碱诱发的癫痫发作使动脉血压、氧分压、葡萄糖、乳酸和肾上腺素显著升高。脑血流量增加了数倍；脑葡萄糖、三磷酸腺苷（ATP）和磷酸肌酸（PCr）没有显著降低。相比之下，窒息期间的癫痫发作与缺氧、低血压、高碳酸血症和酸中毒有关。出现了显著的脑缺血。脑葡萄糖、ATP和PCr显著耗竭。新生犬癫痫发作期间的完全缺氧耗尽了脑能量储备，这导致癫痫活动停止。
