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[蛋氨酸、视黄醇、生育酚和吡哆醇对大鼠煤尘肺模型肺纤维化形成及维生素代谢的影响]

[Effect of methionine, retinol, tocopherol and pyridoxine on fibrogenesis in the lungs and vitamin metabolism in rats in an anthracosis model].

作者信息

Pichkhadze G M

出版信息

Farmakol Toksikol. 1984 Jul-Aug;47(4):98-102.

PMID:6479321
Abstract

It has been discovered in rat experiments that the diet containing an additional amount of methionine and pyridoxine and optimal quantity of fat favoured to a certain degree the retardation of the development of pulmonary fibrosis and reduced the disorders in metabolism of vitamins, characteristic for animals with experimental anthracosis. On the contrary, introduction of an additional amount of retinol into the above complex aggravated the development of pulmonary fibrosis and alterations in vitamin metabolism. At the same time the negative manifestations seen in the animals with experimental anthracosis were removed to a certain measure by administering additional doses of vitamin E.

摘要

在大鼠实验中发现,含有额外量蛋氨酸和吡哆醇以及最佳量脂肪的饮食在一定程度上有利于延缓肺纤维化的发展,并减少了实验性炭疽病动物特有的维生素代谢紊乱。相反,在上述复合物中添加额外量的视黄醇会加重肺纤维化的发展和维生素代谢的改变。同时,通过给予额外剂量的维生素E,实验性炭疽病动物出现的负面表现得到了一定程度的消除。

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