Stanislavchuk N A, Pentiuk A A, Vovk O G, Ostapchuk E I
Eksp Klin Farmakol. 1995 Nov-Dec;58(6):33-5.
The influence of retinol, alpha-tocopherol, and cimetidine on ulceration induced by ortophen, indomethacin, naproxen was studied on rats. It was shown that alfa-tocopherol, retinol, and cimetidine reduce the damaging effect of these drugs on the gastroduodenal mucosa of rats thus normalizing the phospholipid content. The influence of alpha-tocopherol and retinol on the side-effects of ortophen was studied in children with rheumatoid arthritis. Ortophen was found to cause gastroduodenal side-effects in more than 30% of patients and decrease the levels of vitamin A and E in children. The use of retinol and alpha-tocopherol in cotherapy decreases the frequency and severity of side-effects and reduces the vitamin deficiency.
研究了视黄醇、α-生育酚和西咪替丁对大鼠由邻氯苯乙酸、吲哚美辛、萘普生诱导的溃疡的影响。结果表明，α-生育酚、视黄醇和西咪替丁可降低这些药物对大鼠胃十二指肠黏膜的损伤作用，从而使磷脂含量正常化。研究了α-生育酚和视黄醇对类风湿性关节炎患儿使用邻氯苯乙酸产生的副作用的影响。发现邻氯苯乙酸在超过30%的患者中会引起胃十二指肠副作用，并降低儿童体内维生素A和E的水平。联合治疗中使用视黄醇和α-生育酚可降低副作用的发生率和严重程度，并减少维生素缺乏症。
