Kiowski W
Fortschr Med. 1984 Jul 26;102(27-28):721-4.
In the treatment of arterial hypertonia with calcium antagonists good use is made of the vasodilatory effect, which is in the chronic therapy not accompanied by water and volume retention. In three clinical studies it was investigated, which patients could be given a single drug treatment with calcium antagonists. Older patients with a high basal blood pressure and a slight activation of the renin system seem to respond most favourably. Single drug therapy with calcium antagonists is also advantageous for the various illnesses accompanying hypertonia, such as coronary heart disease, cardiac insufficiency, obstructive lung disease or diabetes mellitus.
在使用钙拮抗剂治疗动脉高血压时，充分利用了其血管舒张作用，这种作用在慢性治疗中不会伴有水钠潴留。在三项临床研究中，对哪些患者可以接受钙拮抗剂单药治疗进行了调查。基础血压高且肾素系统轻度激活的老年患者似乎反应最为良好。钙拮抗剂单药治疗对于高血压伴发的各种疾病，如冠心病、心脏功能不全、阻塞性肺病或糖尿病，也具有优势。
