Murata N, Beppu T, Futagawa S, Ushiyama K, Sugiura M, Wada T
Hepatogastroenterology. 1984 Aug;31(4):164-7.
The concentration of total bile acids in the serum was measured in thirty-three patients before and after esophageal transection for esophageal varices, in an attempt to determine the influence of this surgery on the naturally developed portasystemic shunt and also the liver function relating to the bile acid metabolism. The levels of fasting total bile acids in the serum were decreased on the first postoperative day, but gradually increased up to the preoperative levels by the twenty-first postoperative day. The maximum value of total bile acids, as determined in ursodeoxycholic acid tolerance tests, was decreased after the esophageal transection (p less than 0.01). The average of the maximum total bile acids in UDCA tolerance tests was 79.5 microM in the preoperative stage, and 61.0 microM in the postoperative stage. This finding suggested that esophageal transection abolished the portasystemic collaterals and contributed to an increase in efficient hepatic blood flow, which led to the improvement of liver function.
对33例因食管静脉曲张行食管横断术的患者，在术前和术后测定血清总胆汁酸浓度，以确定该手术对自然形成的门体分流的影响以及与胆汁酸代谢相关的肝功能。术后第1天血清空腹总胆汁酸水平下降，但术后第21天逐渐升至术前水平。在熊去氧胆酸耐量试验中测定的总胆汁酸最大值在食管横断术后降低（p<0.01）。术前UDCA耐量试验中总胆汁酸最大值的平均值为79.5μM，术后为61.0μM。这一发现表明，食管横断术消除了门体侧支循环，有助于有效肝血流量增加，从而改善肝功能。
