Wildgrube H J, Mauritz G, Hottenrott C, Böttcher W
Z Gastroenterol. 1983 Oct;21(10):595-600.
In 12 patients with Laennec's cirrhosis conjugated cholic acid was measured by radioimmunoassay simultaneously in the portal vein, the aorta, and the hepatic vein. Furthermore, the concentration was measured for 90 minutes after i. v. injection of cholecystokinin. In the fasting patient the porto-venous extraction ratio was 0.45 (SD 0.23) and the arterio-venous extraction ratio was 0.24 (SD 0,21). 15-30 minutes after cholecystokinin the bile acid concentration significantly increased. In this time the porto-venous extraction ratio rose to 0.71 while the aorto-venous extraction ratio was different. These results agree with the hemodynamics found in cirrhosis. After cholecystokinin the increase in the extraction ratio account for the blood loss by porto venous shunts which corresponds to an increase of the portal compartment.
对12例Laennec肝硬化患者，采用放射免疫分析法同时测定门静脉、主动脉和肝静脉中的结合胆酸。此外，静脉注射胆囊收缩素后90分钟内测定其浓度。在空腹患者中，门静脉-静脉提取率为0.45（标准差0.23），动脉-静脉提取率为0.24（标准差0.21）。注射胆囊收缩素后15 - 30分钟，胆汁酸浓度显著升高。此时门静脉-静脉提取率升至0.71，而主动脉-静脉提取率有所不同。这些结果与肝硬化时的血流动力学情况相符。注射胆囊收缩素后提取率的增加是由于门静脉分流导致的失血，这与门静脉腔的增加相对应。
