Bogardus J B
Hepatology. 1984 Sep-Oct;4(5 Suppl):166S-168S. doi: 10.1002/hep.1840040831.
Monooctanoin is used clinically for dissolution of common bile duct cholesterol gallstones. A number of factors influencing the dissolution rate of cholesterol monohydrate in this solvent were investigated. Water increased cholesterol dissolution rate in a manner inconsistent with previous solubility measurements. Dissolution rate increased approximately 50% in the presence of 10 to 15% water in monooctanoin. Further studies on viscosity, the effect of polymers and temperature showed that the solvent viscosity had a dominating influence on dissolution rate. This was thought to be caused by the interaction of cholesterol with the solvent in the dissolving surface layer which caused a decrease in the diffusion coefficient (and dissolution rate) of cholesterol. Reducing viscosity and increasing temperature were identified as possible approaches for increasing cholesterol gallstone dissolution rate in monooctanoin.
单辛脂在临床上用于溶解胆总管胆固醇结石。研究了多种影响胆固醇单水合物在该溶剂中溶解速率的因素。水以与先前溶解度测量结果不一致的方式提高了胆固醇的溶解速率。在单辛脂中存在10%至15%的水时，溶解速率提高了约50%。对粘度、聚合物的影响和温度的进一步研究表明，溶剂粘度对溶解速率有主导影响。这被认为是由于胆固醇与溶解表面层中的溶剂相互作用，导致胆固醇的扩散系数（和溶解速率）降低。降低粘度和提高温度被确定为提高单辛脂中胆固醇结石溶解速率的可能方法。
