Whittington R M
Hum Toxicol. 1984 Aug;3 Suppl:175S-185S. doi: 10.1177/096032718400300116.
Dextropropoxyphene has been increasingly prescribed as an analgesic in the UK, chiefly in the form of Distalgesic (dextropropoxyphene hydrochloride 32.5 mg and paracetamol 325 mg per tablet). After reports of sudden deaths from the misuse of this combination, prescribing is declining. Distalgesic remains the most common cause of fatal drug overdose in the West Midlands, UK. The 1983 Birmingham inquests are compared with those from the year 1976 to 1979. In comparison with other drug fatalities, death characteristically occurs rapidly, as little as 1 h after ingestion and usually before hospital treatment can be initiated. Toxicity is increased by alcohol which is also extensively abused. The fatal dose may be as small as 15 tablets or possibly less. Many victims are young and some never intended to take their life. Convulsions and respiratory failure precede death. The elderly and respiratory cripples may be more vulnerable to accidental death. Evidence suggests a liability to dependence or even addiction with dextropropoxyphene.
右丙氧芬在英国作为一种镇痛药的处方量越来越大，主要以痛力克（每片含盐酸右丙氧芬32.5毫克和对乙酰氨基酚325毫克）的形式。在有关于滥用这种复方制剂导致猝死的报道后，其处方量正在下降。痛力克仍是英国西米德兰兹地区药物过量致死的最常见原因。将1983年伯明翰的死因调查结果与1976年至1979年的结果进行了比较。与其他药物致死情况相比，死亡通常迅速发生，摄入后短短1小时内，通常在能够开始住院治疗之前。酒精会增加毒性，酒精也被广泛滥用。致死剂量可能低至15片甚至更少。许多受害者很年轻，有些人并非有意自杀。死亡前会出现抽搐和呼吸衰竭。老年人和呼吸功能不全者可能更容易意外死亡。有证据表明右丙氧芬有导致依赖甚至成瘾的倾向。
