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纳洛酮未能逆转痛力克过量所致的心脏毒性。

Failure of naloxone to reverse the cardiotoxocity of Distalgesic overdose.

作者信息

Barraclough C J, Lowe R A

出版信息

Postgrad Med J. 1982 Oct;58(684):667-8. doi: 10.1136/pgmj.58.684.667.

DOI:10.1136/pgmj.58.684.667
PMID:7177993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2426466/
Abstract

A case of severe poisoning with dextropropoxyphene and paracetamol (Distalgesic) in which the cardiotoxic effects of dextropropoxyphene were not reversed by naloxone is reported. A probable reason for this failure is suggested with reference to the differing pharmacological actions of dextropropoxyphene on cardiac conducting tissue and the central nervous system.

摘要

报道了一例右丙氧芬与对乙酰氨基酚(达而丰)严重中毒病例,其中右丙氧芬的心脏毒性作用未被纳洛酮逆转。参照右丙氧芬对心脏传导组织和中枢神经系统不同的药理作用,提出了导致这种治疗失败的一个可能原因。

相似文献

1
Failure of naloxone to reverse the cardiotoxocity of Distalgesic overdose.纳洛酮未能逆转痛力克过量所致的心脏毒性。
Postgrad Med J. 1982 Oct;58(684):667-8. doi: 10.1136/pgmj.58.684.667.
2
Clinical features and management of Distalgesic overdose.
Hum Toxicol. 1984 Aug;3 Suppl:85S-94S. doi: 10.1177/096032718400300110.
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Acute poisoning with Distalgesic.双氯芬酸急性中毒。
Br Med J. 1978 Nov 25;2(6150):1468. doi: 10.1136/bmj.2.6150.1468.
4
Survival after an overdose of Distalgesic (dextropropoxyphene and paracetamol).服用过量达而丰(右丙氧芬和对乙酰氨基酚)后的存活情况。
Ulster Med J. 1989 Oct;58(2):187-9.
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The epidemiology of dextropropoxyphene (Distalgesic) overdose fatalities in Birmingham and the West Midlands.伯明翰和西米德兰兹地区右丙氧芬(痛力克)过量致死的流行病学情况
J Clin Hosp Pharm. 1981 Dec;6(4):251-7. doi: 10.1111/j.1365-2710.1981.tb01001.x.
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Neonatal distalgesic poisoning.
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Management of distalgesic poisoning.
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Dextropropoxyphene overdosage. Pharmacological considerations and clinical management.右丙氧芬过量。药理学考量与临床处理
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Lack of evidence of increased lethality due to propoxyphene overdose in the presence of ethanol in male Wistar rats.在雄性Wistar大鼠中,缺乏证据表明在乙醇存在的情况下,丙氧芬过量会增加致死率。
Arch Toxicol. 1985 Jan;56(3):170-4. doi: 10.1007/BF00333422.
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Dextropropoxyphene overdose. Epidemiology, clinical presentation and management.右旋丙氧芬过量。流行病学、临床表现及处理
Med Toxicol Adverse Drug Exp. 1987 Nov-Dec;2(6):430-44. doi: 10.1007/BF03259877.
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Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine.丙氧芬所致明显的QRS波群异常及钠通道阻滞可被利多卡因逆转。
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本文引用的文献

1
Propoxyphene poisoning. A case complicated by circulatory arrest caused by asystole followed by reversible heart pump failure.
Dan Med Bull. 1971 Dec;18(6):166-8.
2
The management of propoxyphene poisoning.丙氧芬中毒的处理
J Pediatr. 1974 Jul;85(1):98-100. doi: 10.1016/s0022-3476(74)80298-2.
3
Acute poisoning with Distalgesic.双氯芬酸急性中毒。
Br Med J. 1978 Nov 25;2(6150):1468. doi: 10.1136/bmj.2.6150.1468.
4
Electrophysiologic properties of propoxyphene and norpropoxyphene in canine cardiac conducting tissues in vitro and in vivo.丙氧芬和去甲丙氧芬在犬类心脏传导组织中的体外和体内电生理特性。
Toxicol Appl Pharmacol. 1979 Jan;47(1):123-33. doi: 10.1016/0041-008x(79)90079-6.
5
Propoxyphene and norpropoxyphene: pharmacologic and toxic effects in animals.丙氧芬和去甲丙氧芬:对动物的药理和毒性作用
J Pharmacol Exp Ther. 1977 Jan;200(1):245-53.