纳洛酮未能逆转痛力克过量所致的心脏毒性。
Failure of naloxone to reverse the cardiotoxocity of Distalgesic overdose.
作者信息
Barraclough C J, Lowe R A
出版信息
Postgrad Med J. 1982 Oct;58(684):667-8. doi: 10.1136/pgmj.58.684.667.
Abstract
A case of severe poisoning with dextropropoxyphene and paracetamol (Distalgesic) in which the cardiotoxic effects of dextropropoxyphene were not reversed by naloxone is reported. A probable reason for this failure is suggested with reference to the differing pharmacological actions of dextropropoxyphene on cardiac conducting tissue and the central nervous system.
摘要
报道了一例右丙氧芬与对乙酰氨基酚（达而丰）严重中毒病例，其中右丙氧芬的心脏毒性作用未被纳洛酮逆转。参照右丙氧芬对心脏传导组织和中枢神经系统不同的药理作用，提出了导致这种治疗失败的一个可能原因。
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本文引用的文献
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Propoxyphene poisoning. A case complicated by circulatory arrest caused by asystole followed by reversible heart pump failure.
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The management of propoxyphene poisoning.丙氧芬中毒的处理
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Acute poisoning with Distalgesic.双氯芬酸急性中毒。
Br Med J. 1978 Nov 25;2(6150):1468. doi: 10.1136/bmj.2.6150.1468.
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Electrophysiologic properties of propoxyphene and norpropoxyphene in canine cardiac conducting tissues in vitro and in vivo.丙氧芬和去甲丙氧芬在犬类心脏传导组织中的体外和体内电生理特性。
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