变形链球菌核糖体制剂抗体与人心脏和肾脏抗原之间缺乏交叉反应性。
Lack of cross-reactivity of antibodies to ribosomal preparations from Streptococcus mutans with human heart and kidney antigens.
作者信息
Gregory R L, Shechmeister I L, Brubaker J O, Smedberg C T, Michalek S M, McGhee J R
出版信息
Infect Immun. 1984 Oct;46(1):42-7. doi: 10.1128/iai.46.1.42-47.1984.
Previous studies have suggested that sera from animals immunized with whole Streptococcus mutans cells may cross-react with human and monkey heart sarcolemmal tissues. In the present study, sera and saliva from rats and rabbits immunized peripherally with ribosomal preparations from S. mutans 6715 (serotype g) or GS-5 (serotype c) were examined for their ability to react with normal human heart sarcolemmal and kidney glomerular tissues by using enzyme-linked immunosorbent and immunofluorescence assays. The results showed that antibodies to serotype g and c ribosomal preparations do not react with either the human heart or renal antigens. Sera from mice immunized with human heart tissue and from a patient with a high anti-streptolysin O titer reacted strongly with human heart sarcolemmal and kidney glomerular tissues. These data indicated that ribosomal preparations from S. mutans lack the putative human heart cross-reactive determinant and suggest that the use of an S. mutans ribosomal vaccine against dental caries may not be pathogenic to human heart or renal tissues.
先前的研究表明，用变形链球菌全菌免疫动物所获得的血清可能会与人及猴的心脏肌膜组织发生交叉反应。在本研究中，通过酶联免疫吸附测定和免疫荧光测定，检测了用变形链球菌6715（血清型g）或GS-5（血清型c）的核糖体制剂经外周免疫的大鼠和家兔的血清及唾液与正常人心脏肌膜和肾肾小球组织发生反应的能力。结果显示，针对血清型g和c核糖体制剂的抗体不会与人心肌或肾脏抗原发生反应。用人心脏组织免疫的小鼠血清以及抗链球菌溶血素O效价高的患者血清与人心脏肌膜和肾肾小球组织发生了强烈反应。这些数据表明，变形链球菌的核糖体制剂缺乏假定的人心交叉反应决定簇，并提示使用抗龋齿的变形链球菌核糖体疫苗可能不会对人心脏或肾脏组织致病。
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