抗变形链球菌抗体的功能：抗核糖体抗体可抑制酸生成、生长及葡萄糖磷酸转移酶活性。
Function of anti-Streptococcus mutans antibodies: anti-ribosomal antibodies inhibit acid production, growth, and glucose phosphotransferase activity.
作者信息
Gregory R L, Michalek S M, Shechmeister I L, McGhee J R
出版信息
Infect Immun. 1984 Jul;45(1):286-9. doi: 10.1128/iai.45.1.286-289.1984.
Abstract
Antibodies induced in sera and saliva of rats and rabbits immunized with ribosomal preparations from Streptococcus mutans 6715 inhibited transport of glucose by the phosphotransferase system by greater than 60%, acid production from sucrose by greater than 95%, and growth of the homologous S. mutans by greater than 59%. Inhibition of growth and acid production by immune sera and saliva were abrogated by prior adsorption with S. mutans 6715 whole cells, glucosyltransferase, lipoteichoic acid, or alpha 1-6 or alpha 1-3 dextran. These results indicate that antibodies induced to an S. mutans ribosomal preparation react with cell surface determinants and suggest that the antibodies inhibit sucrose-induced acid formation and growth of virulent S. mutans by neutralizing the glucose-phosphotransferase system.
摘要
用变形链球菌6715核糖体制剂免疫的大鼠和兔子血清及唾液中诱导产生的抗体，对磷酸转移酶系统介导的葡萄糖转运的抑制率超过60%，对蔗糖产酸的抑制率超过95%，对同源变形链球菌生长的抑制率超过59%。免疫血清和唾液对生长及产酸的抑制作用，可通过预先用变形链球菌6715全细胞、葡糖基转移酶、脂磷壁酸或α1-6或α1-3葡聚糖吸附而消除。这些结果表明，针对变形链球菌核糖体制剂诱导产生的抗体与细胞表面决定簇发生反应，并提示抗体通过中和葡萄糖-磷酸转移酶系统来抑制蔗糖诱导的产酸及毒性变形链球菌的生长。
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