Erkell L J, Ryd W, Hagmar B
Invasion Metastasis. 1984;4(3):126-33.
We describe the construction of a machine for the injection of 10- to 100-microliter volumes of viable cells in suspension. The cells are maintained in a tissue culture environment and can be injected according to a preprogrammed schedule. Preliminary results show that the tumor incidence and metastasis pattern of TA3Ha cells injected intravenously into mice are the same if the cells are injected in a single dose, or administered in 20 fractions during 3 h.
我们描述了一种用于注射10至100微升悬浮活细胞的机器的构造。细胞被维持在组织培养环境中，并可根据预编程的时间表进行注射。初步结果表明，将TA3Ha细胞静脉注射到小鼠体内时，无论细胞是单次注射还是在3小时内分20次给药，肿瘤发生率和转移模式都是相同的。
