吡啶 - 2 - 醛肟在马拉硫磷中毒中的升压作用。

Pressor action of pyridine-2-aldoxime in malathion poisoning.

Chang P, Ganendran A

Clin Exp Pharmacol Physiol. 1978 Mar-Apr;5(2):125-30. doi: 10.1111/j.1440-1681.1978.tb00662.x.

Abstract

Intravenous injections of pyridine-2-aldoxime (PAM) produced a marked, prolonged and dose-related rise in blood pressure in anaesthetized cats treated with malathion (MT) and without malathion (NMT). 2. The pressor effect of PAM was significantly reduced by phentolamine and phenoxygenzamine, but unaffected by hexamethonium. 3. Pretreatment with guanethidine and reserpine almost completely abolished the pressor response to PAM. 4. The results indicate that PAM has a potent sympathomimetic action which appears to be mediated through release of catecholamines from storage sites.

摘要

给用马拉硫磷（MT）处理过的和未用马拉硫磷（NMT）处理过的麻醉猫静脉注射吡啶 - 2 - 醛肟（PAM），可使血压显著、持久且与剂量相关地升高。2. 酚妥拉明和酚苄明可显著降低PAM的升压作用，但六甲铵对其无影响。3. 用胍乙啶和利血平预处理几乎可完全消除对PAM的升压反应。4. 结果表明，PAM具有强大的拟交感神经作用，这一作用似乎是通过从储存部位释放儿茶酚胺介导的。