Timothy A R, Overgaard J, Overgaard M
Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1765-8. doi: 10.1016/0360-3016(84)90545-5.
Nimorazole, a 5-Nitromidazole compound has been shown in animal studies to have similar radiosensitizing properties to misonidazole at clinically acceptable dose levels. The drug is well absorbed in humans after oral administration with peak plasma levels occurring around 90 min after ingestion (range 35-135 min) and a plasma half life between 2 and 4.8 hours. Total doses of Nimorazole up to 60 grams given in daily doses with conventional radiation therapy have demonstrated a significant lack of side effects, in particular no demonstrable neurotoxicity.
尼莫唑，一种5-硝基咪唑化合物，在动物研究中已表明，在临床可接受的剂量水平下，其具有与米索硝唑相似的放射增敏特性。该药物口服后在人体中吸收良好，摄入后约90分钟（范围为35 - 135分钟）达到血浆峰值水平，血浆半衰期在2至4.8小时之间。在常规放射治疗中，每日给予高达60克的尼莫唑总剂量，已证明其副作用显著缺乏，尤其是未发现明显的神经毒性。
