Edwards M S, Gordon D G, Levin V A, Phillips T L
J Neurooncol. 1984;2(2):91-4.
The effects of misonidazole (MISO) on brain stem evoked potentials (BAEPs) and cortical evoked potentials (CEPs) were evaluated in 16 Sprague-Dawley rats treated with the agent. As found in previous studies, serial BAEP values were diagnostic of the onset of MISO toxicity before clinical signs and symptoms appeared. However, MISO had no effects on CEPs, which remained essentially unchanged through the course of the experiment. At histologic examination, significant changes were found in the area of the brain stem, but there was no histologic evidence of damage to cortical or subcortical structures caused by MISO administration. The results of this study suggest that the neurotoxic effects of MISO are species-specific, and that while the rat model may be useful for comparison of the relative toxic effects of nitroimidazole radiosensitizers, it is not a model suited for measurement of neurotoxicity caused by MISO in humans and nonhuman primates.
在16只接受米索硝唑（MISO）治疗的斯普拉格-道利大鼠中，评估了米索硝唑对脑干诱发电位（BAEP）和皮质诱发电位（CEP）的影响。正如先前研究中所发现的，在临床体征和症状出现之前，连续的BAEP值可诊断米索硝唑毒性的发作。然而，米索硝唑对CEP没有影响，在整个实验过程中CEP基本保持不变。在组织学检查中，发现脑干区域有显著变化，但没有组织学证据表明米索硝唑给药会对皮质或皮质下结构造成损伤。这项研究的结果表明，米索硝唑的神经毒性作用具有物种特异性，虽然大鼠模型可能有助于比较硝基咪唑放射增敏剂的相对毒性作用，但它并不是适合测量米索硝唑在人类和非人类灵长类动物中引起的神经毒性的模型。
