Kun L E, Ho K C, Moulder J E
Cancer. 1982 Feb 1;49(3):423-6. doi: 10.1002/1097-0142(19820201)49:3<423::aid-cncr2820490305>3.0.co;2-l.
A case of fatal encephalopathy following administration of misonidazole (MISO) is reported. Anorexia and dehydration preceded signs of encephalopathy after a cumulative dose of 18 g (11 g/m2) of MISO in five weekly doses. Serum MISO levels four hours after weekly administrations were markedly elevated. Postmortem examination revealed focal cortical neuronal necrosis and hemorrhage with focal demyelination. The possible relationship of dehydration or altered drug metabolism to the development of MISO central nervous system toxicity is noted.
报告了一例使用米索硝唑（MISO）后发生致命性脑病的病例。在每周一次、累计剂量达18克（11克/平方米）的米索硝唑给药后，出现了厌食和脱水症状，随后出现了脑病迹象。每周给药后4小时血清米索硝唑水平显著升高。尸检显示局灶性皮质神经元坏死、出血伴局灶性脱髓鞘。文中指出了脱水或药物代谢改变与米索硝唑中枢神经系统毒性发生之间可能存在的关系。
