Hustead V A, Gutcher G R, Anderson S A, Zachman R D
J Pediatr. 1984 Oct;105(4):610-5. doi: 10.1016/s0022-3476(84)80432-1.
Plasma concentrations of retinol and retinol-binding protein were measured at birth in 91 preterm infants. In 64% of these babies retinol values were less than 20 micrograms/dl, suggestive of vitamin A deficiency. Forty-seven of these infants were observed with sequential measurements of retinol and retinol binding protein through 21 days of age. In babies with respiratory distress syndrome retinol values were similar to those in babies without respiratory distress syndrome. The retinol binding protein levels were lower on the third day of life in babies with respiratory distress syndrome. Babies who developed bronchopulmonary dysplasia had lower concentrations of retinol at birth (P less than 0.05) and on day 21 (P less than 0.05) than did babies who did not develop bronchopulmonary dysplasia, despite receiving recommended intakes of vitamin A. Many preterm infants are deficient in vitamin A at birth, and failure to correct this deficiency may contribute to the development of chronic lung disease.
对91名早产儿出生时的血浆视黄醇和视黄醇结合蛋白浓度进行了测量。在这些婴儿中，64%的视黄醇值低于20微克/分升，提示维生素A缺乏。对其中47名婴儿在出生后21天内对视黄醇和视黄醇结合蛋白进行了连续测量。患有呼吸窘迫综合征的婴儿的视黄醇值与未患呼吸窘迫综合征的婴儿相似。患有呼吸窘迫综合征的婴儿在出生后第三天的视黄醇结合蛋白水平较低。发生支气管肺发育不良的婴儿在出生时（P<0.05）和出生后21天（P<0.05）的视黄醇浓度低于未发生支气管肺发育不良的婴儿，尽管他们摄入了推荐量的维生素A。许多早产儿出生时缺乏维生素A，未能纠正这种缺乏可能会导致慢性肺病的发生。
