Van Winter J T, Stickler G B
J Pediatr. 1984 Oct;105(4):661-5. doi: 10.1016/s0022-3476(84)80444-8.
Panic attack syndrome in four generations of a family and in six additional pediatric patients is reported. The syndrome appears to have an autosomal dominant mode of inheritance. Diagnosis of panic attack syndrome in children has not been reported previously, but the existence of this disorder has been noted for at least 100 years under various synonyms. There is substantial evidence that the syndrome has an endogenous origin and is therefore a biochemical illness. The triggering effect of sodium lactate infusion and the alleviation of symptoms by use of monoamine oxidase inhibitors or beta-blocking agents support this view. Imipramine hydrochloride, propranolol hydrochloride, phenelzine sulfate, and alprazolam are often useful in the treatment of panic attacks, and except for propranolol, any of them may be effective against depression also.
本文报告了一个家族四代人中的惊恐发作综合征以及另外六名儿科患者的情况。该综合征似乎具有常染色体显性遗传模式。此前尚未有关于儿童惊恐发作综合征诊断的报道，但至少在100年里，这种疾病以各种不同的名称被提及。有大量证据表明该综合征源于内因，因此是一种生化疾病。输注乳酸钠的触发效应以及使用单胺氧化酶抑制剂或β受体阻滞剂后症状的缓解支持了这一观点。盐酸丙咪嗪、盐酸普萘洛尔、硫酸苯乙肼和阿普唑仑通常对治疗惊恐发作有效，除普萘洛尔外，它们中的任何一种对治疗抑郁症也可能有效。
