Fujita H, Kondo K, Sears M
Klin Monbl Augenheilkd. 1984 Jul;185(1):28-34. doi: 10.1055/s-2008-1054565.
The invagination of the optic vesicle has, as one of its consequences, the apposition of the apices of the nonpigmented and pigmented epithelia of the ciliary processes of the eye. There are well developed intercellular ciliary "channels" formed at the apices of these cells. Embryologically the ciliary epithelia are homologous to the epithelia of the choroid plexus, a characteristically differentiated ependyma. These epithelial cells have a polarity. For example, the supranuclear region of the nonpigmented epithelia has Golgi apparatus. While stimulation of the epithelia of the choroid plexus by beta adrenergics or cholera toxin increases the rate of production of cerebrospinal fluid, similar stimulation of the adenylate complex within the ciliary epithelia decreases aqueous humor production. When the secretory function of the nonpigmented epithelial cell is activated, fluid is probably reabsorbed from the posterior chamber and secreted apically into the intercellular ciliary channels, in accord with cell polarity, thereby reducing net aqueous inflow. The fluid may enter the ciliary stroma thereafter and thus may become part of what may be called "uveal scleral" flow, or in this instance, uveal flow. The anatomy, physiology, and chemistry fit this hypothesis and form the basis for new investigations of a two-way transport across the ciliary epithelia.
视泡内陷的一个结果是，眼球睫状体非色素上皮和色素上皮的顶端相互并置。在这些细胞的顶端形成了发育良好的细胞间睫状“通道”。从胚胎学角度来看，睫状体上皮与脉络丛上皮同源，脉络丛上皮是一种典型的分化室管膜。这些上皮细胞具有极性。例如，非色素上皮的核上区有高尔基体。虽然β肾上腺素能药物或霍乱毒素刺激脉络丛上皮会增加脑脊液的生成速率，但类似地刺激睫状体上皮内的腺苷酸复合物会减少房水生成。当非色素上皮细胞的分泌功能被激活时，液体可能会从后房被重吸收，并根据细胞极性从顶端分泌到细胞间睫状通道中，从而减少房水的净流入。此后，液体可能进入睫状体基质，因此可能成为所谓“葡萄膜巩膜”流的一部分，在这种情况下即葡萄膜流。解剖学、生理学和化学符合这一假设，并为跨睫状体上皮双向运输的新研究奠定了基础。
