一种加压素拮抗剂肽[dPtyr(Me)AVP]对加压素（AVP）在抑制性回避作用方面的拮抗作用。
Antagonism of effects of vasopressin (AVP) on inhibitory avoidance by a vasopressin antagonist peptide [dPtyr(Me)AVP].
作者信息
LeBrun C J, Rigter H, Martinez J L, Koob G F, Le Moal M, Bloom F E
出版信息
Life Sci. 1984 Oct 1;35(14):1505-12. doi: 10.1016/0024-3205(84)90168-1.
After training in two different passive avoidance tasks, the platform box of Ader and De Wied (1972) and the Jarvik box of Jarvik and Kopp (1967), rats injected with vasopressin immediately following the training trial showed a significant enhancement of retention 24 hours later. This vasopressin effect was reversed by high doses of the vasopressor antagonist, dPtyr(Me) AVP. These results support the hypothesis that the visceral afferent signals may be involved in the apparent memory-enhancing effects of AVP, but the high doses of antagonist required suggest that factors other than a simple reversal of the pressor effects of AVP may be important.
在接受两种不同的被动回避任务训练后，即阿德和德维德（1972年）的平台箱任务以及贾维克和科普（1967年）的贾维克箱任务，在训练试验后立即注射加压素的大鼠在24小时后表现出显著增强的记忆保持能力。高剂量的血管升压拮抗剂dPtyr(Me) AVP可逆转这种加压素效应。这些结果支持了这样一种假设，即内脏传入信号可能参与了加压素明显的记忆增强作用，但所需的高剂量拮抗剂表明，除了简单地逆转加压素的升压作用之外，其他因素可能也很重要。
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