Dockter G, Steyns M, Biro G, Sitzmann F C
Monatsschr Kinderheilkd. 1984 Aug;132(8):589-93.
Serum immunoreactive trypsin (IRT) was measured in cord blood and blood specimens of 156 healthy children of different age. These results were compared with the IRT of children with gastrointestinal disease. While IRT from newborn is significantly elevated, mean trypsin levels form older children do not differ from those found in adults. In acute pancreatitis too, as in renal failure, trypsin is elevated. Low trypsin values were estimated in acute hepatitis and Crohn's disease. In cystic fibrosis (CF) serum trypsin levels depend on the exocrine function of the pancreas. The IRT assay on dried blood-spots, seems to become a reliable and convenient neonatal screening test for CF in newborns.
对156名不同年龄段健康儿童的脐带血和血液样本进行了血清免疫反应性胰蛋白酶（IRT）检测。将这些结果与患有胃肠道疾病儿童的IRT进行比较。虽然新生儿的IRT显著升高，但大龄儿童的平均胰蛋白酶水平与成年人的并无差异。在急性胰腺炎中，如同在肾衰竭中一样，胰蛋白酶水平也会升高。在急性肝炎和克罗恩病中估计胰蛋白酶值较低。在囊性纤维化（CF）中，血清胰蛋白酶水平取决于胰腺的外分泌功能。干血斑上的IRT检测似乎正在成为一种可靠且便捷的新生儿CF筛查检测方法。
