Teufel M, Luik G, Niessen K H
Monatsschr Kinderheilkd. 1986 Mar;134(3):132-7.
The number of peptide hormones which have been localized in the gut and in neurons of the central and peripheral nervous system has increased considerably. As there is almost no information about their importance in children with gastrointestinal diseases, we developed highly sensitive radioimmunoassays and measured postprandial serum/plasma levels of gastrin, secretin, vasoactive intestinal polypeptide (VIP) and motilin in 112 healthy children (N), 28 patients with cystic fibrosis (CF) and 17 children with Crohn's disease (CD). Gastrin values were not pathologic in children with CF nor those with Crohn's disease (N = 56.2 +/- 29.6 pg/ml; CF = 57.0 +/- 34.2 pg/ml; CD = 43.6 +/- 26.6 pg/ml). A significant age dependency was established for secretin and VIP. These peptides were elevated in CF-patients. In children with Crohn's disease only Secretin was increased. Motilin was elevated in all patients: N = 78.0 (49.1-124.0) pg/ml; CF = 148.0 (70.8-309) pg/ml; CD = 153.0 (87.6-266).
已确定位于肠道以及中枢和外周神经系统神经元中的肽类激素数量大幅增加。由于几乎没有关于它们在患有胃肠疾病儿童中的重要性的信息，我们开发了高灵敏度放射免疫分析法，并测量了112名健康儿童（N组）、28名囊性纤维化（CF）患者和17名克罗恩病（CD）儿童餐后血清/血浆中胃泌素、促胰液素、血管活性肠肽（VIP）和胃动素的水平。CF患儿和克罗恩病患儿的胃泌素值均无病理性改变（N组 = 56.2 ± 29.6 pg/ml；CF组 = 57.0 ± 34.2 pg/ml；CD组 = 43.6 ± 26.6 pg/ml）。促胰液素和VIP呈现出显著的年龄依赖性。这些肽类在CF患者中升高。在克罗恩病患儿中，仅促胰液素升高。所有患者的胃动素均升高：N组 = 78.0（49.1 - 124.0）pg/ml；CF组 = 148.0（70.8 - 309）pg/ml；CD组 = 153.0（87.6 - 266）。
