7埃分辨率下核小体核心颗粒的结构。
Structure of the nucleosome core particle at 7 A resolution.
作者信息
Richmond T J, Finch J T, Rushton B, Rhodes D, Klug A
出版信息
Nature. 1984;311(5986):532-7. doi: 10.1038/311532a0.
DOI:10.1038/311532a0
PMID:6482966
Abstract
The crystal structure of the nucleosome core particle has been solved to 7 A resolution. The right-handed B-DNA superhelix on the outside contains several sharp bends and makes numerous interactions with the histone octamer within. The central turn of superhelix and H3 . H4 tetramer have dyad symmetry, but the H2A . H2B dimers show departures due to interparticle associations.
摘要
核小体核心颗粒的晶体结构已解析到7埃分辨率。外侧的右手螺旋B型DNA含有几个急转弯，并与内部的组蛋白八聚体发生大量相互作用。超螺旋的中心转折和H3·H4四聚体具有二元对称性，但H2A·H2B二聚体由于颗粒间的缔合而出现偏离。
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