Rosenbluth J, Blakemore W F
Neurosci Lett. 1984 Jul 27;48(2):171-7. doi: 10.1016/0304-3940(84)90015-6.
Axons in chronically demyelinated spinal cord lesions, induced by ethidium bromide injection, display patches of intramembranous particles and indentations resembling nodal and paranodal axolemmal specializations respectively. Both occur in the marginal region of the lesions where the demyelinated axons are intimately associated with astrocytic and oligodendrocytic processes, and probably correspond to the aberrant node-like and paranodal junctional complexes seen in thin sections of this region. Demyelinated axons in the center of the lesion, which are not in contact with glial processes, do not display these membrane specializations.
通过注射溴化乙锭诱导形成的慢性脱髓鞘脊髓损伤中的轴突，分别呈现出膜内颗粒斑块和类似于结区及结旁轴膜特化的凹陷。两者都出现在损伤的边缘区域，在此区域脱髓鞘轴突与星形胶质细胞和少突胶质细胞的突起紧密相连，并且可能对应于该区域薄片中所见的异常结样和结旁连接复合体。损伤中心未与胶质突起接触的脱髓鞘轴突则未表现出这些膜特化。
