Gewitz M H, Tait M S
Pediatr Pharmacol (New York). 1984;4(2):109-13.
Pulmonary extraction of radiolabeled norepinephrine (NE) was evaluated in newborn rabbits aged 1 to 3 days. Twenty pups were raised from birth in an hypoxic environment (FiO2 = 0.16-0.17) and 10 were raised in room air for study as controls. NE extraction was measured using an isolated, perfused lung technique. In hypoxic animals, average percent removal of NE was significantly reduced (p less than 0.05) as compared to controls while pulmonary pressures were increased (p less than 0.05) compared to controls. The data suggest that hypoxia reduces the ability of the lung to clear norepinephrine. This may be a factor in systemic and pulmonary vasomotor responses to hypoxia.
对1至3日龄新生兔的肺脏摄取放射性标记去甲肾上腺素（NE）的情况进行了评估。20只幼兔自出生起饲养于低氧环境（吸入氧分数=0.16 - 0.17），10只在室内空气中饲养作为对照用于研究。采用离体灌注肺技术测量NE摄取情况。与对照组相比，低氧动物中NE的平均清除百分比显著降低（p<0.05），而肺压与对照组相比升高（p<0.05）。数据表明，低氧会降低肺脏清除去甲肾上腺素的能力。这可能是对低氧的全身和肺血管运动反应的一个因素。
