Sommerwerck D, Simon C, Friehoff J
Dtsch Med Wochenschr. 1978 May 12;103(19):822-5. doi: 10.1055/s-0028-1104518.
Minocycline concentrations in serum, saliva, sputum, pleural exudate and lung extracts after a single dose of 0.2 g (orally or intravenously) were measured on 32 patients with bronchial or lung disease. On the first day of treatment, concentrations in purulent sputum were five to ten times higher than in mucous sputum and saliva, after two hours they were one third, after three hours half the serum concentration (0.7 and 1.0 microgram/ml, respectively). After six hours the concentration was the same (1.6 microgram/ml). On the third day of treatment (after 0.2 g every 24 hours) concentrations in purulent sputum were higher than on the first day by 0.8 microgram/ml (after two hours) and by 0.95 microgram/ml (after three hours). After one-hour i.v. infusion of 0.2 g minocycline concentrations in mucous sputum and saliva rose more quickly on the first day than after oral administration. On the third day of treatment (after 0.1 g orally every 12 hours) pleural exudate level was almost as high as serum level. Minocycline concentration in lung extract on the third day of treatment--four, five and ten hours after the last dose--was 0.4 and 0.8 microgram/g, respectively (while serum concentration at the same time was 1.0-1.5 microgram/ml).
对32例支气管或肺部疾病患者单次口服或静脉注射0.2g米诺环素后，测定其血清、唾液、痰液、胸腔渗出液及肺提取物中的米诺环素浓度。治疗第一天，脓性痰液中的浓度比黏液性痰液和唾液中的浓度高5至10倍，两小时后为其三分之一，三小时后为血清浓度的一半（分别为0.7和1.0微克/毫升）。六小时后浓度相同（1.6微克/毫升）。治疗第三天（每24小时服用0.2g后），脓性痰液中的浓度在两小时后比第一天高0.8微克/毫升，三小时后高0.95微克/毫升。静脉输注0.2g米诺环素一小时后，黏液性痰液和唾液中的浓度在第一天比口服给药后上升得更快。治疗第三天（每12小时口服0.1g后），胸腔渗出液水平几乎与血清水平一样高。治疗第三天（最后一剂后4、5和10小时）肺提取物中的米诺环素浓度分别为0.4和0.8微克/克（而同时血清浓度为1.0 - 1.5微克/毫升）。
