Bafundo K W, Baker D H, Fitzgerald P R
Poult Sci. 1984 Aug;63(8):1594-603. doi: 10.3382/ps.0631594.
Several experiments were performed with young chicks to evaluate lead (Pb) toxicity and its effect upon copper (Cu) and zinc (Zn) toxicosis in the presence or absence of Eimeria acervulina infection. Toxic levels of Pb (3300 mg/kg) and Cu (500 mg/kg) or Zn (2000 and 4000 mg/kg) were added to completely adequate corn-soybean meal diets, while duodenal coccidiosis was produced by multiple crop inoculations of 4 X 10(5) sporulated E. acervulina oocysts. Both Pb and Cu depressed gain and feed efficiency while concomitant coccidial infection reduced these parameters further. Moreover, E. acervulina increased the concentration of liver Cu and kidney Pb. Although Pb supplementation slightly decreased the accumulation of liver Cu, additional Cu tended to increase the deposition of Pb in the kidney in both infected and uninfected birds. Similarly, chick performance was significantly reduced by excess dietary Pb or Zn, although coccidiosis slightly ameliorated the growth depression caused by toxic levels (4000 mg/kg) of Zn. Although 4000 ppm Zn and coccidial infection reduced the deposition of Pb in the kidney, this interaction was not evident when 2000 mg/kg Zn was fed to infected chicks. It is evident that Pb toxicosis in the chick is affected little by excess dietary levels of either Cu or Zn.
用幼雏进行了多项实验，以评估在存在或不存在堆型艾美耳球虫感染的情况下铅（Pb）的毒性及其对铜（Cu）和锌（Zn）中毒的影响。将毒性水平的铅（3300毫克/千克）和铜（500毫克/千克）或锌（2000和4000毫克/千克）添加到营养完全充足的玉米-豆粕日粮中，同时通过多次接种4×10⁵个孢子化的堆型艾美耳球虫卵囊来诱发十二指肠球虫病。铅和铜均降低了体重增加和饲料效率，而同时发生的球虫感染则进一步降低了这些参数。此外，堆型艾美耳球虫增加了肝脏铜和肾脏铅的浓度。尽管补充铅略微降低了肝脏铜的积累，但额外添加铜在感染和未感染的禽类中都倾向于增加铅在肾脏中的沉积。同样，过量的日粮铅或锌会显著降低雏鸡的生产性能，尽管球虫病略微缓解了由毒性水平（4000毫克/千克）的锌引起的生长抑制。尽管4000 ppm的锌和球虫感染减少了铅在肾脏中的沉积，但当给感染的雏鸡饲喂2000毫克/千克的锌时，这种相互作用并不明显。显然，雏鸡中的铅中毒受日粮中过量的铜或锌的影响很小。
