Bafundo K W, Baker D H, Fitzgerald P R
Poult Sci. 1984 Sep;63(9):1828-32. doi: 10.3382/ps.0631828.
The purpose of this study was to evaluate the effects of Eimeria acervulina infection (duodenal coccidiosis) on cadmium (Cd) toxicity and zinc (Zn) status in the young chick. Additions of Cd (45 mg/kg) were made to diets that contained either 0 or 52 mg/kg supplemental Zn (from ZnCO3). Duodenal coccidiosis was produced by multiple crop inoculations of 4 X 10(5) sporulated E. acervulina oocysts. Growth and efficiency of feed utilization were reduced by dietary Cd addition while concurrent coccidial infection reduced these parameters further. Addition of Cd also increased Cd content of liver and kidney and depressed hemoglobin, hematocrit, and plasma Zn content. Coccidial infection exacerbated tissue Cd deposition and depressed hematological parameters further. Although dietary Zn addition ameliorated some of the adverse effects of Cd toxicity, Cd administration tended to enhance tissue Zn deposition. Administration of Cd enhanced synthesis of metallothionein.
本研究的目的是评估堆型艾美耳球虫感染（十二指肠球虫病）对雏鸡镉（Cd）毒性和锌（Zn）状态的影响。在含有0或52 mg/kg补充锌（来自碳酸锌）的日粮中添加镉（45 mg/kg）。通过多次嗉囊接种4×10⁵个孢子化的堆型艾美耳球虫卵囊来诱发十二指肠球虫病。日粮中添加镉会降低生长速度和饲料利用效率，而同时感染球虫会使这些参数进一步降低。添加镉还会增加肝脏和肾脏中的镉含量，并降低血红蛋白、血细胞比容和血浆锌含量。球虫感染会加剧组织镉沉积，并进一步降低血液学参数。尽管日粮中添加锌可改善镉毒性的一些不良影响，但施用镉往往会增强组织锌沉积。施用镉会增强金属硫蛋白的合成。
