Lang G F, Walton J S, Etches R J
Poult Sci. 1984 Sep;63(9):1861-71. doi: 10.3382/ps.0631861.
An injection of 200 mg aminoglutethimide (AG)/kg body weight (BW) given 9 hr before spontaneous midcycle ovulation reliably blocked ovarian steroidogenesis and ovulation. Reduction of the dose to 100 mg AG/kg BW or injection of either dose 7 hr before ovulation partially blocked steroidogenesis and failed to reliably inhibit ovulation. Both doses of AG given either 7 or 9 hr before ovulation completely inhibited estradiol-17 beta secretion. Plasma concentrations of progesterone were partially reduced by 100 mg AG/kg BW and were completely suppressed by the 200 mg/kg BW dose of AG. Plasma testosterone levels were depressed only by 200 mg AG/kg BW. Plasma corticosterone levels were elevated following all injections of AG. In the absence of ovarian steroidogenesis, the plasma concentration of luteinizing hormone either remained stable or decreased slightly. Estradiol-17 beta synthesis or release is not required for ovulation, because, in some cases, ovulation occurred in the absence of this hormone. Derangement of the ovarian hierarchy usually occurred when AG was given 7 hr but not 9 hr before ovulation.
在自发的周期中期排卵前9小时注射200毫克氨鲁米特（AG）/千克体重（BW）可可靠地阻断卵巢类固醇生成和排卵。将剂量减至100毫克AG/千克体重或在排卵前7小时注射任一剂量，均可部分阻断类固醇生成，且未能可靠地抑制排卵。在排卵前7小时或9小时给予的两种剂量的AG均可完全抑制雌二醇-17β的分泌。100毫克AG/千克体重可部分降低血浆孕酮浓度，而200毫克/千克体重的AG剂量可完全抑制孕酮分泌。仅200毫克AG/千克体重可降低血浆睾酮水平。所有AG注射后血浆皮质酮水平均升高。在缺乏卵巢类固醇生成的情况下，促黄体生成素的血浆浓度要么保持稳定，要么略有下降。排卵并不需要雌二醇-17β的合成或释放，因为在某些情况下，排卵可在缺乏这种激素的情况下发生。当在排卵前7小时而非9小时给予AG时，卵巢层级通常会紊乱。
