Platel A, Jalfre M, Pawelec C, Roux S, Porsolt R D
Pharmacol Biochem Behav. 1984 Aug;21(2):209-12. doi: 10.1016/0091-3057(84)90216-8.
The effects of various piracetam + choline combinations on an experimental model of memory were investigated. Mice were given two sessions in a simple photo-cell activity cage and the decrease in activity at the second session (habituation) served as an index of retention. Retention was facilitated by post-session administration of 2000 mg/kg piracetam IP and 50 mg/kg piracetam + 50 mg/kg choline IP. Similar injections of choline alone (10 to 200 mg/kg IP), piracetam alone (10 to 1000 mg/kg IP) or other combinations of piracetam and choline were without effect. These results, consistent with those reported elsewhere, suggest that piracetam can interact with choline to facilitate memory processes in mice.
研究了各种吡拉西坦与胆碱组合对记忆实验模型的影响。在一个简单的光电活动笼中对小鼠进行两个阶段的实验，第二阶段（习惯化）活动的减少作为记忆保持的指标。腹腔注射2000mg/kg吡拉西坦和腹腔注射50mg/kg吡拉西坦 + 50mg/kg胆碱后给药可促进记忆保持。单独腹腔注射类似剂量的胆碱（10至200mg/kg）、单独注射吡拉西坦（10至1000mg/kg）或吡拉西坦与胆碱的其他组合均无效果。这些结果与其他地方报道的结果一致，表明吡拉西坦可与胆碱相互作用以促进小鼠的记忆过程。
