Means L W, Comer T R, Moore R
Psychology Department, East Carolina University, Greenville, NC.
J Neural Transm Gen Sect. 1991;85(2):109-16. doi: 10.1007/BF01244703.
Sprague-Dawley rats given either 5 or 10 mg/kg of a new compound, BMY 21502, 150 mg/kg of piracetam or a dose of methylcellulose vehicle (p.o.) daily for 38 days beginning two days before training were compared on performance of a win-stay water-escape task in a circular water maze requiring the use of working memory. The task involved giving the rats pairs of trials in which the location of a submerged escape platform remained the same within a pair of trials but changed semirandomly across pairs. Rats receiving either 5 mg/kg BMY 21502 or piracetam made more correct choices than did rats receiving only the vehicle (p less than 0.05 in each case). The facilitated performance was associated with making fewer perseverative responses that resulted in errors.
从训练前两天开始，将斯普拉格-道利大鼠每日口服给予5或10毫克/千克的新化合物BMY 21502、150毫克/千克的吡拉西坦或一剂甲基纤维素赋形剂，持续38天。在需要使用工作记忆的圆形水迷宫中的赢则停留水迷宫任务表现上，对这些大鼠进行了比较。该任务包括对大鼠进行成对试验，其中在一对试验中水下逃生平台的位置保持不变，但在各对试验之间半随机变化。接受5毫克/千克BMY 21502或吡拉西坦的大鼠比仅接受赋形剂的大鼠做出了更多正确选择（每种情况下p均小于0.05）。表现的改善与导致错误的持续性反应减少有关。
